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Influence of ethanol and ethanol-induced lipid peroxidation on the steroidogenic activity of testicles

Kashko, M.F.; Khokha, A.M.; Antsulevich, S.N.; Doroshkevich, N.A.; Voronov, P.P.

Ukrainskii Biokhimicheskii Zhurnal 65(2): 89-94

1993

ISSN/ISBN: 0201-8470
PMID: 8236538
Document Number: 417890
Chronic alcohol intoxication results in the diminished testosterone level and activation of lipid peroxidation in rat testes. A significant decrease in 3 beta-hydroxysteroid-hydrogenase and 17-dehydrogenase activity has been observed in microsomes. Analogous shifts have been evoked in vitro by the induction of lipid peroxidation in microsomes. That permitted one to suppose that alcohol-induced alterations in tests are partially mediated by induction of lipid peroxidation.

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