Effect of phensuccinal on lipid metabolism, lipid peroxidation, and antioxidant system activity in rabbits with dithiazone-induced diabetes
Gorbenko, N.I.; Poltorak, V.V.; Gladkikh, A.I.; Ivanova, O.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 66(4): 39-42
2003
ISSN/ISBN: 0869-2092 PMID: 14558351 Document Number: 558817
A three-month administration of phensuccinal improved glucose homeostasis, decreased the levels of total cholesterol, triglycerides, fatty acids, and low-density lipoproteins in the blood serum, and reduced the lipid peroxidation rate as compared to the untreated diabetic control. In addition, phensuccinal increased the content of the antiatherogenic high-density lipoprotein fraction and the related paraoxonase enzyme activity. The preventive effect of phensuccinal with respect to diabetic dyslipidemia development, together with the antioxidant action, show this compound to be a promising therapeutic means of preventing and/or reducing macrovascular complications in diabetic patients.