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Effect of antihypertensive therapy on indices for lipid peroxidation and antioxidant system in patients with hypertensive heart

Serkova, V.K.; Burdeĭnaia, L.V.

Likars'ka Sprava 2002(5-6): 12-16

2002

ISSN/ISBN: 1019-5297
PMID: 12442509
Document Number: 550270
In treating patients with hypertensive heart, effects of drugs on processes of lipoperoxidation should be taken into account since in heart remodelling there occurs an imbalance between peroxide oxidation on lipids and bodily antioxidant system of defence. Most investigators believe that calcium antagonists, beta- and alpha-adrenoblockers, inhibitors of the angiotensin-converting enzyme, nitrates, and some diuretics exert in some way or other a positive effect on the above imbalance. Further studies are warranted on a new class of hypotensive drugs--antagonists of angiotensin II receptors to free-radical oxidation of lipids.

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