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The monooxygenase system, lipid peroxidation in the liver and vitamin B12 metabolism in experimental poisoning of rabbits with phenylhydrazine

Poznanskaia, A.A.; Korsova, T.L.; Morozova, N.A.; Tsukerman, E.S.; Kurganov, B.I.

Biokhimiia 54(8): 1290-1293

1989

ISSN/ISBN: 0320-9725
PMID: 2819103
Document Number: 346306
It has been demonstrated that phenylhydrazine poisoning results in a significant activation of lipid peroxidation, reduction of dimethylaniline N-demethylation and NADPH-2.6-dichlorophenolindophenol and NADPH-cytochrome c-reductase activities as well as in the stimulation of the NADPH-nitrotetrazolium reductase activity in rabbit liver microsomes. In addition, phenylhydrazine administration causes disturbances in vitamin B12 metabolism which are manifested as changes in total cobalamin pool and in the spectrum of vitamin B12 individual physiologically active forms in the blood.

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