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Ethanol enhances the stimulatory effects of insulin and insulin-like growth factor-1 on DNA synthesis in NIH 3T3 fibroblasts

Tomono, M.; Kiss, Z.

Biochemical and Biophysical Research Communications 208(1): 63-67

1995

ISSN/ISBN: 0006-291X
PMID: 7887966
Document Number: 444795
In practically all in vitro experimental systems examined so far, including embryonal fibroblasts, ethanol was shown to inhibit cell growth. Here we report that in NIH 3T3 fibroblasts. (patho)physiologically relevant concentrations (50-100 mM) of ethanol significantly (2- to 2.8-fold) enhanced the stimulatory effects of both insulin and insulin-like growth factor-1 on DNA synthesis. Ethanol had no major effects on the mitogenic effects of platelet-derived growth factor, fibroblast growth factor and lyso-phosphatidic acid. These data suggest that ethanol is not a universal inhibitor of cell growth.

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