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1,3-disubstituted 2-thioxo-4,5-imidazolidinediones and 2,4,5-imidazolidinetriones and their anticonvulsant activity

Zankowska-Jasińska, W.; Borowiec, H.; Kolasa, A.; Ostrowska, K.; Zaleska, B.; Przemyk, B.; Krzywosiński, L.; Bogdal, M.; Kieryłowicz, H.

Polish Journal of Pharmacology and Pharmacy 42(1): 59-68

1990

ISSN/ISBN: 0301-0244
PMID: 2281021
Document Number: 3668
New unsymmetrically 1,3-disubstituted derivatives of 2-thioxo-4,5-imidazolidinedione (3, 5-7, 9-12) and 2,4,5-imidazolidinetrione (2, 8, 13-15) were synthesized by condensation of the respective thioureas and ureas with oxalyl chloride. They were screened for their central, mainly anticonvulsant activity and only compound 8 revealed antianxiety and antiepileptic properties.

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1,3-disubstituted 2-thioxo-4,5-imidazolidinediones and 2,4,5-imidazolidinetriones and their anticonvulsant activity

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