Synthesis of some indane derivatives of central muscle relaxant and anticonvulsant profiles
Abdallah, N.A.; el-Shabrawy, O.; el-Eraky, W.
Farmaco 52(12): 733-739
1997
ISSN/ISBN: 0014-827X PMID: 9648278 Document Number: 480859
A series of 2,2-bis(hydroxymethyl)indane derivatives 1a-f, 2a-e and 3a-f were synthesized to investigate their central muscle relaxant and anticonvulsant activities. The synthesized compounds 1a-f, 2a-e and 3a-f were found to be devoid of central muscle relaxant activity using meprobamate (100 mg/kg) as a reference standard. However, they showed remarkable anticonvulsant properties in a dose of 80 mg/kg (s.c.) compared with diphenylhydantoin sodium (80 mg/kg) as a reference standard.