Synthesis and activity of some quinolone derivatives against Plasmodium falciparum in vitro
Domínguez, J.; Basante, W.; Charris, J.; Riggione, F.
Farmaco 51(6): 407-412
1996
ISSN/ISBN: 0014-827X PMID: 8766223 Document Number: 463507
Quinolones 7a-i and 8a-i were synthesized and tested in vitro as antimalarial against Plasmodium falciparum in chloroquine resistant strain. The above compounds were inactive at concentrations of 1.0 times 10-4 M except the quinolone 3-amino-9-(2,4-dichlorophenyl)-1H-pyrazolo (3,4b)-4-quinolone 7h which showed IC-50 of 5.06 mu-M given the most interesting results.
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