In vitro activities of seven quinolone derivatives against Neisseria gonorrhoeae

Van der Willigen, A.H.; Degener, J.E.; Vogel, M.; Stolz, E.; Wagenvoort, J.H.

Arzneimittel-Forschung 40(6): 684-685

1990


ISSN/ISBN: 0004-4172
PMID: 2118763
Document Number: 354910
The in vitro activities of ciprofloxacin, enoxacin, fleroxacin, lomefloxacin, norfloxacin, ofloxacin, and pefloxacin against 10 penicillinase-producing N. gonorrhoeae strains (PPNG's), 10 non-PPNG's, 10 non-penicillinase-producing penicillin-resistant chromosomally mediated N. gonorrhoeae strains (CMRNG's) 3 N. gonorrhoeae strains with a decreased sensitivity against quinolones compounds and one tetracycline-resistant penicillinase-producing N. gonorrhoeae (TRNG/PPNG), strain were evaluated in this study. The non PPNG, PPNG, CMRNG and TRNG/PPNG strains showed good to excellent sensitivity to the quinolones tested. The N. gonorrhoeae strains with a decreased sensitivity against quinolones showed higher MIC (minimum inhibitory concentration) values.

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