In vitro bacteriostatic and bactericidal effect of ciprofloxacin and others quinolone derivatives on Campylobacter jejuni
Vanhoof, R.; Hubrechts, J.M.; Roebben, E.; Leger, J.; De Schepper, N.
Pathologie-Biologie 36(2): 163-166
1988
ISSN/ISBN: 0369-8114 PMID: 3279386 Document Number: 308010
The in vitro bacteriostatic (MIC) and bactericidal (MBC) activities of ciprofloxacin and seven other quinolone derivatives on Campylobacter jejuni from human origin were determined. Ciprofloxacin, pefloxacin and rosoxacin exhibited the best bacteriostatic and bactericidal activities. For the three compounds the MIC90 was less than or equal to 0.33 microgram/ml while the MBC90 was resp. 0.36, 0.56 and 0.56 microgram/ml. The MBC values were always significantly higher than the MIC values (P less than 0.001). An attempt was made to select strains with an induced resistance against the quinolone derivatives.