In vivo bactericidal effect of ciprofloxacin, ofloxacin and pefloxacin against Staphylococcus aureus
Tronel, H.; Voiriot, P.; Weber, M.; Dopff, C.; Dewachter, P.; Phelisse, F.; Dureux, J.B.
Pathologie-Biologie 37(5 Part 2): 578-581
1989
ISSN/ISBN: 0369-8114 PMID: 2797882 Document Number: 329245
The bactericidal activity of ciprofloxacin, ofloxacin, pefloxacin, against methicillin sensitive S. aureus (2 different strains) was studied on a model of infected fibrin clots inserted subcutaneously in rabbit. The quinolones were delivered intravenously, as a single daily dose of 100 mg/kg/day. The bactericidal activity was evaluated by determining for various time points (1 h, 2 h, 6 h, 12 h, and 24 h after the infusion of the antibiotics), viable organisms in the dissolved clots. This study shows that: 1) No significant difference appears between the quinolones studied. 2) The in vivo early bactericidal activity of quinolones against S. aureus appears to be better than oxacillin but lesser than oxacillin-netilmicin combination.