Association of mutations in grlA and gyrA topoisomerase genes with resistance to ciprofloxacin in epidemic and sporadic isolates of methicillin-resistant Staphylococcus aureus
Deplano, A.; Zekhnini, A.; Allali, N.; Couturier, M.; Struelens, M.J.
Antimicrobial Agents and Chemotherapy 41(9): 2023-2025
1997
ISSN/ISBN: 0066-4804 PMID: 9303407 Document Number: 478164
The types of topoisomerase alterations in genomically diverse epidemic and sporadic strains of methicillin and fluoroquinolone-resistant Staphylococcus aureus isolated from European hospitals between 1984 and 1994 were characterized. Convergent dual mutations in gyrA (codon 83, 84, or 88) and grlA (codon 79 and/or 80) were found in all strains exhibiting high-level resistance to ciprofloxacin (MIC, 16 to gtoreq 128 mu-g/ml). In some epidemic strains, the resistant phenotype and genotype appeared in the 1990s and persisted thereafter.