Antibiotic sensitivity of Plasmodium falciparum in vitro
Raichowdhuri, A.N.; Gajanana, A.
Indian Journal of Medical Research 80: 103-106
1984
ISSN/ISBN: 0019-5340 PMID: 6394480 Document Number: 227491
Efficacy of 11 antibiotics were tested in vitro against 2 strains of P. falciparum sensitive to chloroquine and pyrimethamine and 1 strain resistant to both the antimalarial compounds. Ampicillin, streptomycin, kanamycin, chloramphenicol, erythromycin and chlortetracycline were ineffective, in the concentrations tested. Oxytetracycline, demeclocycline, doxycycline, clindamycin and lincomycin were effective in concentration equivalent to or less than the human therapeutic plasma levels. Synchronized culture studies suggested that these antibiotics act on the schizonts and that the sensitivity of field isolates can be determined by a 48 h test.