Studies on the synthesis and bioactivity of some new shikimic acid derivatives
Sun, K.L.; Li, R.S.; Lei, X.H.
Yao Xue Xue Bao 25(1): 73-76
1990
ISSN/ISBN: 0513-4870 PMID: 2363361 Document Number: 348536
Ten new shikimic acid derivatives, some of which are analogs of dioxolamycin were synthesized from methyl shikimate because the bioactivity of shikimic acid derivatives has received considerably less attention to date. Compounds 4-10, 12, 16 were subjected to antimicrobial test in vitro, and showed no activity (MIC greater than 25 micrograms/ml). Compounds 4-10, 12, 13, and 16 were subjected to cytostatic activity test against cultured L 1210 Leukemia cells in vitro. Compounds 4, 6, 13 and 16 showed cytostatic activity like dioxolamycin.