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Cancerostatics. IV. on the synthesis of some noval 1-Azacarbazole derivatives as antineoplastic agents

Kaczmarek, L.; Nantka-Namirski, P.

Polish Journal of Pharmacology and Pharmacy 33(1): 121-127

1981

ISSN/ISBN: 0301-0244
PMID: 7255278
Document Number: 179196
By condensation of 2-chloro-3-nitropyridine with some anilines the corresponding 2-anilino-3-nitropyridines 1a--11 were obtained. Hydrogenation of these compounds and subsequent diazotization of the 2-anilino-3-aminopyridine derivatives 2a--2l gave triazoles 3a--3l which thermally decomposed in PPA or in liquid paraffine afforded the required 6- and 8-substituted 1-azacarbazole derivatives 4a--3, i--l. Some of these compounds showed significant activity against transplanted mouse sarcoma 180. None of them were active against L 1210 and P 388 leukemias.

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