Synthesis and antimicrobial activity of N-Mannich bases of 3-[N'-sulphadoximino] isatin and its methyl derivative
Surendra; Pandeya, N.; Yogeeswari, P.; Ram, D.S.; Nath, G.
Bollettino Chimico Farmaceutico 137(8): 321-324
1998
ISSN/ISBN: 0006-6648 PMID: 9835147 Document Number: 497375
Schiff's bases of isatin and 5-methyl isatin with sulphadoxine and then its N-Mannich bases were synthesised and evaluated for their anti-microbial activity. The piperidonemethyl group improved the activity and most of the compounds were more potent than the pure drugs.
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