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Neuropharmacological actions of some newly synthesized Mannich bases

Tongia, S.K.; Trivedi, C.P.; Matkar, S.V.; Chouhan, R.S.; Kaushal, R.

Indian Journal of Physiology and Pharmacology 25(3): 269-273

1981

ISSN/ISBN: 0019-5499
PMID: 7298153
Document Number: 171967
Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.

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