Evaluation of the cytotoxicity of some Mannich bases of acetophenone against the EMT6 tumour
Dimmock, J.R.; Erciyas, E.; Raghavan, S.K.; Kirkpatrick, D.L.
Die Pharmazie 45(10): 755-757
1990
ISSN/ISBN: 0031-7144 PMID: 2089386 Document Number: 352133
1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably.