Antithyroid activity of various newly synthesized 1,3-thiazine derivatives
Detiuk, E.S.; Turkevich, N.M.; Avgustinovich, M.S.; Kolosova, L.G.; Vyshemirskaia, L.D.
Problemy Endokrinologii 22(4): 103-107
1976
ISSN/ISBN: 0375-9660 PMID: 69301 Document Number: 106746
Experiments were performed on rats. It was revealed that three newly-synthesized 1,3-thiazine derivative (1,3-thiazandithion-2,4, 1,3-thiazanthion-2-on-4-thiosemicarbazone-4, and 1,3-thiazandion-2,4) possessed and antithyroidal action in doses equal to 15% of LD50; in the two former preparations it was accompanied by an goiterogenic effect. 1,3-thiazandion-2,4 had the most antithyroidal action and relatively weak goiterogenic effect.