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Preliminary pharmacological evaluation of newly synthesized derivatives of phosphonoamino acids

Kleinrok, Z.; Kolasa, K.; Mastalerz, P.; Kafarski, P.

Polish Journal of Pharmacology and Pharmacy 38(5-6): 435-442

1986

ISSN/ISBN: 0301-0244
PMID: 3575164
Document Number: 269105
Ten newly synthesized derivatives of phosphonoamino acids were subjected to preliminary pharmacological evaluation in mice and rats. We investigate their effect on acute toxicity, body temperature spontaneous and exploratory activity, electrogenic and pentetrazole convulsions, and motor coordination and .gamma.-aminobutyric as acid concentration in various brain regions. The most active derivatives were .alpha.-amino-.alpha.-p-hydroxyphenyl-methylphosphonic acid 40, .beta.-(.alpha.-aminoethyl)-carbamoyl-ethylphosphonic acid 43, .alpha.-amino-.beta.-phenylethylphosphonic acid 46, and .alpha.-amino-.beta.-(p-nitrophenyl)-ethylphosphonic acid 47. Those compounds depressed the spontaneous locomotor activity and displayed protective action in electrogenic and penetetrazole convulsions.

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Belcheva, I.; Stoytchev, T. 1983: Neuropharmacological activity of newly-synthesized derivatives of 3,3-diethyl-2,4-pyridinedione. V. Relation between chemical structure and pharmacological activity Acta Physiologica et Pharmacologica Bulgarica 9(4): 37-47
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Detiuk, E.S.; Turkevich, N.M.; Avgustinovich, M.S.; Kolosova, L.G.; Vyshemirskaia, L.D. 1976: Antithyroid activity of various newly synthesized 1,3-thiazine derivatives Problemy Endokrinologii 22(4): 103-107
Mitcheva, M.; Vitcheva, V.; Manolov, I.; Valkova, I. 2002: Effects of two newly synthesized 4-hydroxycoumarin derivatives (4-OHC) on isolated rat hepatocytes Methods and Findings in Experimental and Clinical Pharmacology 24(6): 345-349
Raĭnova, L.; Staneva, D.; Chakŭrova, L. 1982: Comparative pharmacological study of efortil with a newly synthesized derivative of 2-aminotetralin Eksperimentalna Meditsina i Morfologiia 21(4): 183-186
Jagiełło-Wójtowicz, E.; Zebrowska-Lupina, I.; Wielosz, M.; Stelmasiak, M.; Szurska, G.; Porowska, A.; Kleinrok, Z. 1984: Preliminary pharmacological evaluation of new imidazolidinone-2, ethylenediamine and imidazoline derivatives Acta Poloniae Pharmaceutica 41(4): 495-504
Kirakosyan, G.; Torgomyan, H.; Malakyan, M.; Bajinyan, S.; Trchounian, A. 2013: Protective effect of some amino acids synthesized derivatives and their chelates on Escherichia coli under X-ray irradiation Indian Journal of Biochemistry and Biophysics 50(4): 289-295
Zawadzka, J.; Bogdal, M. 1984: Thiazole derivatives. V. Synthesis and pharmacological screening of amides of 4-phenyl-5-thiazolecarboxylic acids Acta Poloniae Pharmaceutica 41(6): 633-640
Nawojski, A.; Liszkiewicz, H.; Nawrocka, W.; Wilimowski, M.; Barczyńska, J.; Kedzierska, L.; Wojewódzki, W.; Rutkowska, M.; Duś, E.; Szelag, A. 1988: Synthesis and preliminary pharmacological studies on dihydropyrido-1,3,4-triazepinone derivatives Polish Journal of Pharmacology and Pharmacy 40(1): 63-71
Filczewski, M.; Paszek, T.; Oledzka, K.; Ernest, K.; Waliszewski, T. 1974: Preliminary pharmacological studies on the hypotensive and adrenolytic action of a series of new piperazine derivatives Acta Poloniae Pharmaceutica 31(4): 555-563
Faff, J.; Woliński, J.; Bandolet, J.; Bak, W. 1978: Preliminary screening of anticholinergic effect of some new derivatives of glycolic and aminoacetic acids Polish Journal of Pharmacology and Pharmacy 30(4): 497-499
Tongia, S.K.; Trivedi, C.P.; Matkar, S.V.; Chouhan, R.S.; Kaushal, R. 1981: Neuropharmacological actions of some newly synthesized Mannich bases Indian Journal of Physiology and Pharmacology 25(3): 269-273
McIlwain, D.L.; Hoke, V.B. 1988: Allocation of newly synthesized proteins in spinal motoneurons Revue Neurologique (Paris) 144(11): 697-700
Bellani, P.; Clavenna, G.; Sosio, A. 1984: Synthesis and pharmacological evaluation of imidazopyridinium derivatives as neuromuscular blocking agents Il Farmaco; Edizione Scientifica 39(10): 846-862
Czopek, A.; Zagorska, A.; Kolaczkowski, M.; Bucki, A.; Gryzlo, B.; Rychtyk, J.; Pawlowsk, M.; Siwek, A.; Satala, G.; Bojarski, A.; Kubacka, M.; Filipek, B. 2016: New Spirohydantoin Derivatives - Synthesis, Pharmacological Evaluation, and Molecular Modeling Study Acta Poloniae Pharmaceutica 73(6): 1545-1554
Gauchy, C.; Kemel, M.L.; Glowinski, J.; Besson, M.J. 1981: In vivo release of newly synthesized GABA in the basal ganglia of the cat Advances in Biochemical Psychopharmacology 29: 183-191
Sato, W.; Fukazawa, N.; Suzuki, T.; Yusa, K.; Tsuruo, T. 1991: Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073 Cancer Research 51(9): 2420-2424
Igarashi, T.; Yamamoto, M.; Yamada, M.; Ogata, E.; Katsuragi, S. 1982: Application of newly synthesized 1-34 human parathyroid hormone for diagnostic tests Pharmatherapeutica 3(2): 79-85
Chiueh, C.C.; Moore, K.E. 1975: D-amphetamine-induced release of "newly synthesized" and "stored" dopamine from the caudate nucleus in vivo Journal of Pharmacology and Experimental Therapeutics 192(3): 642-653
Eisenhofer, G.; Ropchak, T.G.; Kopin, I.J.; Goldstein, D.S. 1988: Release, metabolism and intraneuronal disposition of exogenous, endogenous and newly synthesized norepinephrine in the rat vas deferens Journal of Pharmacology and Experimental Therapeutics 245(1): 81-88