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Preliminary pharmacological investigation on 38 aminophosphonic acids and their derivatives

Kleinrok, Z.; Kolasa, K.; Chodkowska, A.; Mastalerz, P.; Kafarski, P.

Polish Journal of Pharmacology and Pharmacy 37(5): 575-584

1985

ISSN/ISBN: 0301-0244
PMID: 3008130
Document Number: 4487
Central pharmacological properties of 38 aminophosphonic acids and their derivatives, mostly newly synthesized, were investigated on mice and rats. Acute toxicity, neurotoxic activity, influence on spontaneous locomotor activity, body temperature, electrogenic and pentetrazol convulsions, on cerebral GABA level were tested. The most active compounds were (in a decreasing order of activity): 2-amino-7-phosphonoheptanoic, 2-amino-5-phosphonovaleric, 2-amino-8-phosphonooctanoic, 2-amino-2-methyl-3-methylphosphonopropionic, and 3-amino-3-hydroxy-5-phosphonovaleric acid.

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Preliminary pharmacological investigation on 38 aminophosphonic acids and their derivatives

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