Synthesis, characterization and antimicrobial activity of 1,5-bis[2- (hydroximino) -1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide and 1,5-bis[2- (hydroximino) -3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide
Patil, M.V.; Malve, S.P.
Acta Poloniae Pharmaceutica 61(2): 135-138
2004
ISSN/ISBN: 0001-6837 PMID: 15493296 Document Number: 568568
1,5-Bis[2-(hydroximino)-1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide [IV] and 1,5-bis[2-(hydroximino)-3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide [V] were synthesized by the reaction of thiocarbonohydrazide [I] with either 3-(hydroximino)-pentane-2,4-dione [II] or 2-(hydroximino)-1-phenyl-butane-1,3-dione [III] in a 1:2 molar proportion, respectively. Compounds [IV] and [V] were characterized by elemental analyses, IR and PMR spectroscopic studies. These newly synthesized compounds have been screened or their antimicrobial activity against S. aureus, S. typhi. C. albicans, T. mentagrophytes, T. rubrum and M. tuberculosis.