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Effect of a newly developed platinum compound cis-1, 1-cyclobutane dicarboxylato- (2R) -2-methyl-1,4-butane diamine platinum (II) , on human ovarian tumors transplanted into nude mice

Sawada, M.; Ozaki, M.; Taniguchi, H.; Tateishi, R.; Mori, Y.; Mino, K.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 15(4 Part 1): 637-641

1988

ISSN/ISBN: 0385-0684
PMID: 3355185
Document Number: 322042
The therapeutic effect of cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II) (NK 121) on 3 human yolk sac tumors of the ovary (YST-1, YST-2 and YST-3), which were transplanted into nude mice, was compared with that of cisplatin (CDDP). While tumors YST-2 and YST-3 exhibited a broad comparable sensitivity to CDDP and NK 121, YST-1 was substantially more sensitive to CDDP than NK 121. A significant weight loss was noted in the non-tumor bearing nude mice treated with CDDP, as compared with the loss in both control and NK 121-treated groups. NK 121 showed a good antitumor activity without showing severe toxicities.

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Boven, E.; van der Vijgh, W.J.; Nauta, M.M.; Schlüper, H.M.; Pinedo, H.M. 1985: Comparative activity and distribution studies of five platinum analogues in nude mice bearing human ovarian carcinoma xenografts Cancer Research 45(1): 86-90
Endo, K.; Akamatsu, K.; Matsumoto, T.; Morikawa, K.; Koizumi, M.; Mitsui, H.; Koizumi, K. 1992: Antitumor effects of three platinum complexes, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)-platinum (II) monohydrate (DWA2114R), cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) (CBDCA) and cis-diamminedichloroplatinum(II) (CDDP), in mice Anticancer Research 12(1): 49-58
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Hamad, S.A.; Beale, P.; Yu, J.Qing.; Huq, F. 2014: Synthesis and antitumour activity of a new trinuclear platinum compound [{cis-PtCl(NH3)2μ {trans-Pt(3-hydroxypyridine)2H2N(CH2)5NH2)2}] Cl4 in human ovarian cancer cells Anticancer Research 34(4): 1923-1929
Hannemann, J.; Baumann, K. 1988: Inhibition of lactate-dehydrogenase by cisplatin and other platinum-compounds: enzyme leakage of LDH is not a suitable method to measure platinum-compound-induced kidney cell damage in vitro Research Communications in Chemical Pathology and Pharmacology 60(3): 371-379
Shen, M.; Feng, Y.; Zhou, X. 1999: Effect of liposome-C-erbB2 antisense oligodeoxynucleotides on the growth and the chemotherapeutic drug sensitivity of human ovarian cancer transplanted in the omentum of nude mice Zhonghua Fu Chan Ke Za Zhi 34(2): 110-112
Linasmita, V.; Wilailak, S.; Srisupundit, S.; Tangtrakul, S.; Bullangpoti, S.; Israngura, N. 1998: Epithelial ovarian cancer treated by platinum or platinum analogue with cyclophosphamide: experience in Ramathibodi Hospital Journal of the Medical Association of Thailand 81(1): 10-16
Okazaki, M.; Kubota, T.; Hanatani, Y.; Maruyama, K.; Tsuyuki, K.; Nakada, M.; Asanuma, F.; Ishibiki, K.; Abe, O. 1982: Microvascular architecture of human tumors transplanted in nude mice--its relationship to sensitivity to antineoplastic agents Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(8): 1433-1441
Gotoh, A.; Mizuno, Y.; Matsuwari, S.; Kitazawa, S.; Maeda, S.; Arakawa, S.; Kamidono, S. 1994: Evaluation of the anticancer effect of cisplatin and etoposide against nude mice transplanted urological malignant tumors Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(6): 899-902
Kikkawa, F.; Kojima, M.; Oguchi, H.; Maeda, O.; Ishikawa, H.; Tamakoshi, K.; Mizuno, K.; Kawai, M.; Suganuma, N.; Tomoda, Y. 1993: Potentiating effect of amphotericin B on five platinum anticancer drugs in human cis-diamminedichloroplatinum (II) sensitive and resistant ovarian carcinoma cells Anticancer Research 13(4): 891-896
Wei, L.H. 1989: Experimental heterotransplantation of human ovarian tumors in nude mice Zhonghua Fu Chan Ke Za Zhi 24(1): 32-34; 58-59
Ross, S.A.; Carr, C.A.; Brïet, J.W.; Lowe, G. 2000: Transfer of 4'-chloro-2,2':6',2"-terpyridine platinum(II) between human serum albumin, glutathione and other thiolate ligands. a possible selective natural transport mechanism for the delivery of platinum(II) drugs to tumour cells Anti-Cancer Drug Design 15(6): 431-439
Guo, W.; He, R.G.; Zhang, Z.Y. 1992: The antitumor effect of DNL/rIL-2 and Pingyangmycin on human tongue carcinoma(Tca 8113) transplanted to Nude Mice Shanghai Kou Qiang Yi Xue 1(1): 40-42
Wang, J.; Huang, C.; Wei, X.-Y.; Zhan, Z.-L.; Sun, H.; Yang, Y.; Li, K. 2008: Biological effect of endostatin on transplanted human lung adenocarcinoma Calu-6 tumor in nude mice Zhonghua Zhong Liu Za Zhi 30(4): 266-269
Fujii, G.; Sekiguchi, M.; Samaru, Y.; Miyamoto, Y.; Koishi, T.; Suzuki, K.; Sudo, K. 1979: Effect of lymphoid cells sensitized in vitro on the growth of autochthonous human gastric cancer transplanted in "nude mice" Japanese Journal of Experimental Medicine 49(3): 219-222
Hinkelbein, W.; Wallbrecher, E.; Fiebig, H.H.; Wannenmacher, M. 1989: Fractionated irradiation under ambient conditions of human NSCLC transplanted into nude mice: effect of different fractionation schedules and of radiotherapy and vindesine Strahlentherapie und Onkologie: Organ der Deutschen Rontgengesellschaft . 165(7): 519-520
Fukatsu, H.; Yamada, H.; Nonomura, H.; Miyagawa, Y.; Hatano, Y.; Waki, M.; Hiraiwa, S.; Muramatsu, T.; Yamada, Y.; Nishikawa, E. 1987: Study on heterotransplantation of human malignant urogenital tumors in nude mice: establishment of the tumor line in nude mice from human primary ureteral tumor and its characteristics Hinyokika Kiyo. Acta Urologica Japonica 33(12): 1943-1950
Welch, R.S.; James, R.D.; Wilkinson, P.M.; Belli, F.; Cowan, R.A. 1995: Recombinant human erythropoietin and platinum-based chemotherapy in advanced ovarian cancer Cancer Journal from Scientific American 1(4): 261-266