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Synthesis and biochemical evaluation of N- (1-substituted-cycloalkyl) -beta- (3,4-dimethoxy; or dihydroxy) phenethylamines: potential dopaminergic agents

Shafik, R.M.; Rida, S.M.; Eshba, N.H.; Abdel-Kreem, M.F.; el-Dardiry, S.A.

Farmaco 50(4): 273-279

1995

ISSN/ISBN: 0014-827X
PMID: 7669172
Document Number: 448398
The design and synthesis of some hybrid-structures comprising the dopamine framework on one hand and an N-(1-substituted-cyclo alkyl) moiety on the other have been elaborated. Selective members of the new series were biochemically assayed to determine their effects on the levels of dopamine and its metabolite norepinephrine in brains of Albino-rats. The brain MAO activity was also estimated. The results were compared with those displayed by apomorphine, metoclopramide and PCP.

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