The synthesis of alternating alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3') - and (5'-->5') -internucleotic linkages as potential therapeutic agents
Koga, M.; Geyer, S.J.; Regan, J.B.; Beaucage, S.L.
Nucleic Acids Symposium Series 29: 3-4
1993
ISSN/ISBN: 0261-3166 PMID: 8247779 Document Number: 420522
A simplified synthesis of alpha-2'-deoxyribonucleoside derivatives has been developed and the solid-phase preparation of antisense alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotidic phosphodiester linkages, targeted against HIV-1 tat mRNA, has been accomplished. Hybridization properties of these oligonucleotide analogues have been investigated.