Glycosidopyrroles. Part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2-propoxy)methylpyrroles as potential antiviral agents

Almerico, A.M.; Diana, P.; Barraja, P.; Dattolo, G.; Mingoia, F.; Putzolu, M.; Perra, G.; Milia, C.; Musiu, C.; Marongiu, M.E.; Almerico, A.M; Diana, P; Barraja, P; Dattolo, G; Mingoia, F; Putzolu, M; Perra, G; Milia, C; Musiu, C; Marongiu, M.E

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Glycosidopyrroles. Part 2. Acyclic derivatives: 1- (1,3-dihydroxy-2-propoxy) methylpyrroles as potential antiviral agents

Almerico, A.M.; Diana, P.; Barraja, P.; Dattolo, G.; Mingoia, F.; Putzolu, M.; Perra, G.; Milia, C.; Musiu, C.; Marongiu, M.E.

Farmaco 52(11): 667-672

1997

ISSN/ISBN: 0014-827X

PMID: 9550092

Document Number: 475059

The series of 1-(1,3-dihydroxy-2-propoxy)methylpyrroles 2a-o were prepared in good overall yields according to Scheme I. When evaluated for antiviral activity against HIV-1, only compounds of the triphenyl series (R3 = NH2, N3, Br) were found to inhibit the HIV-1 replication at concentrations that were very not cytotoxic for MT-4 cells, with selectivity index 1.5-9.3. None of these compounds showed antibacterial or antifungal activity.