Studies on uranium mobilization agents VI: synthesis of 2,3-dihydroxy-4-carbomethoxybenzyl aminocarboxylic acid amides chelating agents
Qin, Z.H.; Xie, Y.Y.
Yao Xue Xue Bao 28(8): 619-622
1993
ISSN/ISBN: 0513-4870 PMID: 8285072 Document Number: 412347
In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N-(substituted carbamoylmethyl)-2,3-dihydroxy-4-carbomethoxybenzylamine was synthesized starting with o-vanillin. The effect on detoxication Of UO-2(NO-3)-2, CuSO-4 and NiCl-2 in mice was tested. Some of them (IVa, IVd, IVf and IVg) were shown to be good antidotes for acute uranium intoxication, but all were less effective for Cu-2+ and Ni-2+.