Spermatocidal action of some fat-soluble chelating agents in pouches of caudae epididymides in rats
Yu, Z.H.
Zhongguo Yao Li Xue Bao 3(4): 260-263
1982
ISSN/ISBN: 0253-9756 PMID: 6219543 Document Number: 5778
The rat cauda epididymis was made into a pouch by 2 ligatures. Such a simple operation was used for screening spermatocides. Fifteen different com- pounds were separately injected into the pouches, and the sperms in them were examined after 2 d. Three fat-soluble chelating agents (salicylaldehyde, o-vanillin and 8- hydroxyquinoline), like gossypol, killed the sperms in cauda epididymis. However, unlike gossypol, they did not impair the spermatogenesis after ig 40 mg/rat daily for 40 d except Sundays. As a spermatocide, BAL was less effective than salicylaldehyde, o-vanillin, 8-hydroxyquinoline and gossypol. Three water-soluble chelating agents (EDTA, DTPA and thiourea) did not kill the sperms directly.
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