Novobiocin: further observations
Martin, W.J.; Heilman, F.R.; Nichols, D.R.; Wellman, W.E.; Geraci, J.E.
Antibiotic Medicine and Clinical Therapy 2(4): 258-267
1956
ISSN/ISBN: 0570-3107 PMID: 13303121 Document Number: 9459
It is apparent from these and previous data that novobiocin is excreted slowly and that antibiotic activity remains in the blood for relatively long periods. Despite this finding, there is no evidence that novobiocin piles up in the serum of patients receiving the agent for a week or more. There is considerable variation in the concentration of novobiocin in the serum following oral administration, not only from patient to patient, but in the same patient. A higher concentration of this agent in the serum may indicate a lesser concentration in the feces, and the converse. Preliminary clinical experience with novobiocin is encouraging. This antibiotic proved highly effective in the treatment of 4 of 5 patients with micrococcal bacteremia; in the fifth patient allergic dermatitis made discontinuation of therapy with the agent necessary. Satisfactory clinical response followed the use of novobiocin in 3 of 4 patients with infections of the skeletal system. The agent was used successfully in 5 cases of micrococcal enterocolitis. Allergic dermatitis is a common reaction to the agent, which paradoxically may militate against its indiscriminate use.
Document emailed within 1 workday
