Action of novobiocin on the capacity of Nocardia fructiferi var. ristomycini for ristomycin biosynthesis
Toropova, E.G.; Egorov, N.S.; Bal'zhinovagiĭn, T.; Tkhaker, V.
Antibiotiki 25(11): 815-817
1980
ISSN/ISBN: 0003-5637 PMID: 6255857 Document Number: 159135
The effect of novobiocin in concentrations of 0.05 and 0.2--0.3 microgram/ml on morphological variation of N. fructifer and its capacity for ristomycin production was studied. It was found that the number of colonies with the maximum activity increased under the effect of novobiocin used in a concentration of 0.05 microgram/ml. An increase in the level of novobiocin in the medium up to 0.2--0.3. microgram/ml markedly increased the number of the colonies with low antibiotic productivity.