A study of the sensitizing potential of novobiocin
Welch, H.; Lewis, C.N.; Putnam, L.E.; Randall, W.A.
Antibiotic Medicine and Clinical Therapy 3(1): 27-32
1956
ISSN/ISBN: 0570-3107 PMID: 13340683 Document Number: 8168
Of 208 adult male subjects administered 10 Gm. of novobiocin orally over a 12 day period, only 1 exhibited a drug rash (less than 0.5 per cent). Three of the 208 subjects showed a yellow discoloration of the sclerae which faded gradually on discontinuation of the drug. The suggestion is made that the relatively high percentage of skin rashes reported during early clinical use of novobiocin may be related to the dose and number of days of treatment. Because of the relatively high activity of novobiocin against susceptible microorganisms and the extremely high blood concentrations obtained with relatively low doses of this drug, it is proposed that doses of 0.5 Gm. twice daily should be ample for most susceptible infections. Through use of such a regimen, annoying skin rashes previously reported following use of this drug may be kept at a minimum.
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