The radiation-sensitizing effect of isometronidazole following its intravesical application in bladder carcinoma. a clinical phase-Ii study
Kob, D.; Lilienthal, A.; Bauhardt, H.; Merkle, K.; Schröder, E.; Schröder, E.; Hentschel, M.
Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft . 167(9): 530-533
1991
ISSN/ISBN: 0179-7158 PMID: 1925936 Document Number: 382474
The radiosensitizing efficacy of iso-metronidazole, a 4-nitroimidazole derivative, was evaluated in a prospective clinical phase-II study. The results of combined radiotherapy of 25 patients with bladder cancer were compared with those of a control group of 25 patients treated with radiotherapy only. Tumor regression six months after radiotherapy was used as an endpoint. The surgical procedure was performed as double TUR. Evaluating the local tumor control after additional application of iso-metronidazole a gain factor of 1.2 is obtained.