Studies in potential antifertility agents: part 20: Synthesis of tetraphenylethane basis ethers & 1, 2-Bis (4'-hydroxyphenyl) -1,2-diphenylethylene
Iyer, R.N.; Rao, K.V.B.
Indian Journal of Chemistry. Sect. B 16(7): 601-604
1978
ISSN/ISBN: 0376-4699 PMID: 12261415 Document Number: 543
Tetraphenylethane basic ethers have been synthesized and screened for their antifertility activity. Some of them showed significant activity. 2-(4'beta Diethylaminoethoxyphenyl)-l,1-diphenylethane appears to be the most active as it prevents implantation in rates at 3.5 mg/kg. The stucture relationship activity in the series are discussed. The unreacted methyl ether (2.5 g) was recovered from the benzene layer. 1,2-Bis (4'-acetoxyphenyl)-1,2-diphenylethylene--1,2-Bis (4'-hydroxyphenyl)-1,2-diphenylethylene (1-2g) was dissolved in acetic anhydride (6 ml) and dry pyridine (0.5) added. After 24 hours the reaction mixture was poured over crushed ice and the white product that separated was filtered and crystallized from ethanol; m.p. 163 degrees; NMR (CDC13); 2.98(m, 18H, Ar-H), 7.79 (s, 6H, -0-COCH3) (Fourd: C, 79.99; H, 5.70. C30H2404 requires C, 80.36; H, 5.36%).
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