Synthesis of 5-imino-5H-dipyrido[1,2-a; 2',3'-d]pyrimidines as potential antiallergy agents (1)
Rykowski, A.; Pucko, W.
Acta Poloniae Pharmaceutica 56(1): 57-60
1999
ISSN/ISBN: 0001-6837 PMID: 10635352 Document Number: 509554
A novel route to 5-imino-5H-dipyrido[1,2-a; 2',3'-d]pyrimidines is described. The method is based on the Ullmann condensation of 2-chloro-3-cyano-5-nitropyridine with 2-amino-pyridine 1-oxides, followed by intramolecular cyclization of the resulting 2-(3-cyano-5-nitro-2-pyridylamino)pyridine 1-oxides with phosphorous trichloride.
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