Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents
Kojima, E.; Shirasaka, T.; Machida, M.; Yoshioka, H.; Murakami, K.; Mitsuya, H.
Nucleic Acids Symposium Series 25: 91-92
1991
ISSN/ISBN: 0261-3166 PMID: 1668777 Document Number: 375240
In order to study the structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential anti-retroviral agents, various purine derivatives have been synthesized and tested against rous sarcoma virus (RSV) in chick embryo fibroblast (CEF) cells, and against human immunodeficiency virus (HIV) in human CD4+ T cells (ATH8). Some of the new purine derivatives found to be significant antiretroviral activities. And the correlations of activity between anti-RSV and anti-HIV have shown fairly good values so far.