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Synthesis and antileishmanial activity of some 1- or 2- (dihydroxyalkyl) and 3- (dihydroxyalkoxy) pyrazolo [3,4-d] pyrimidines

Gatta, F.; Gradoni, L.; Lupardini, E.; Gramiccia, M.; Orsini, S.

Farmaco 46(1): 75-84

1991

ISSN/ISBN: 0014-827X
PMID: 2054043
Document Number: 375349
Several new derivatives of 4-amino-, 4,6-diamino- and 4-hydrazino-[3,4-d]pyrimidine dihydroxyalkyl substituted in the first or 2nd positions, or dihydroxyalkoxy substituted in the 3rd position were synthesized. Some of these compounds were evaluated for their activity against Leishmania infantum in mice. The highest degree of antileishmanial activity was displayed by the 4-amino-1-(dihydroxyalkyl) derivatives which yielded inhibition values nearly comparable with that of glucantime in a standard 5-day test.

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