Synthesis and binding study on pyrazolo[4,5-c] [1,8]naphthyridines
Cecchi, L.; Colotta, V.; Filacchioni, G.; Melani, F.; Palazzino, G.; Galli, A.
Il Farmaco; Edizione Scientifica 42(9): 671-680
1987
ISSN/ISBN: 0430-0920 PMID: 2826226 Document Number: 300715
Following our previous reports on pyrazolo[4,5-c]quinoline derivatives some isosteric pyrazolo[4,5-c] [1,8]naphthyridines were synthesized and tested for their ability to displace [3H]flunitrazepam from rat brain membranes. The lack of activity of the synthesized compounds and structure-activity relationships for the whole series are discussed.
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