1,4-Dimethoxy-9(10H)-acridinone derivatives. Synthesis, DNA binding studies and trypanocidal activity

Berny, H.; Bsiri, N.; Charbit, J.J.; Galy, A.M.; Soyfer, J.C.; Galy, J.P.; Barbe, J.; Sharples, D.; Mesa Valle, C.M.; Mascaro, C.; Berny, H; Bsiri, N; Charbit, J.J; Galy, A.M; Soyfer, J.C; Galy, J.P; Barbe, J; Sharples, D; Mesa Valle, C.M; Mascaro, C

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1,4-Dimethoxy-9 (10H) -acridinone derivatives. Synthesis, DNA binding studies and trypanocidal activity

Berny, H.; Bsiri, N.; Charbit, J.J.; Galy, A.M.; Soyfer, J.C.; Galy, J.P.; Barbe, J.; Sharples, D.; Mesa Valle, C.M.; Mascaro, C.

Arzneimittel-Forschung 42(5): 674-679

1992

ISSN/ISBN: 0004-4172

PMID: 1530683

Document Number: 389235

New acridinonic derivatives, which are hydroxy- and methoxy-substituted in positions 1, 4, and 1,4 were prepared with a view to obtain antiparasitic drugs. These compounds were tested against Trypanosoma cruzi strains and their capability of interacalation into DNA was determined. Nucleus substituents, DNA binding, and trypanocidal activities have been correlated.