Synthesis and antihypertensive activity of novel 1- (4-benzyl-1-phthalazinyl) -pyrazolo[3,4-d]pyrimidines
El-Feky, S.A.; Abd el-Samii, Z.K.
Die Pharmazie 51(8): 540-543
1996
ISSN/ISBN: 0031-7144 PMID: 8794464 Document Number: 469439
Convenient Syntheses of derivatives of the pyrazolo[3,4-d]pyrimidines from 1-(4-benzyl-1-phthalazinyl)-3-amino-4-cyano-5-methylpyrazole (1) and carbon disulphide, aryl isothiocyanates, nitriles or guanidine are described. Derivatives of compound 1 undergo cyclization to the titled ring system by action of dimethylformamide dimethylacetal or hydrogen sulphide followed by treatment with triethylamine. Some of the new compounds were studied as antihypertensive agents.