Synthesis of 4-Chloro-6- (substituted-phenyl) -pyrimidines
Németh, G.áb.; Varga, Z.án.; Greff, Z.án.; Kéri, G.ör.; Orfi, L.ás.ó
Acta Pharmaceutica Hungarica 80(3): 101-108
2010
ISSN/ISBN: 0001-6659 PMID: 21222319 Document Number: 644096
4-Phenylamino-6-phenyl-pyrimidine is a common core structure of several, important enzyme inhibitors. The common key intermediate of these compounds, 4-chloro-6-substituted phenyl pyrimidine, was synthesised by conventional methods without the application of special catalysts in contrary to the published methods. Here we present two different synthetic procedures for the preparation of the title compound. The results of these processes depend on the substituent of the 6-phenyl ring as it is demonstrated on the presented examples. The reactions can be performed via traditional heating either with microwave assistance.