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Substances with antiviral activity. XIII. Synthesis and in vitro activity of thiosemicarbazones of 1-benzoyl- and 1-benzyl-2-chloro-3-formylindoles

Cavrini, V.; Gatti, R.; Giovanninetti, G.; Chiarini, A.; Franchi, L.; Landini, M.P.

Il Farmaco; Edizione Scientifica 35(8): 636-641

1980

ISSN/ISBN: 0430-0920
PMID: 6256213
Document Number: 156047
A series of 1-benzoyl- and 1-benzyl-2-chloro-3-formylindole thiosemicarbazones was synthesized and investigated for antiviral activity against vaccinia virus IHD strain and parainfluenza virus type 3, HA-I/CR-8 strain. The results confirmed the previously observed high activity against vaccinia virus of m-substituted benzoyl derivatives. On the contrary, the analogous benzyl derivatives showed marginal activity; the compound (V c), however, was the most active against the parainfluenza virus.

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Duckert, F. 1970: Hereditary deficiency in factor XIIi activity-synthesis of a non-functional protein Schweizerische Medizinische Wochenschrift 100(7): 328
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Tsilevich, T.L.; Shchaveleva, I.L.; Nosach, L.N.; Zhovnovataia, V.L.; Smirnov, I.P. 1988: Acyclic analogs of ribavirin. Synthesis and antiviral activity Bioorganicheskaia Khimiia 14(5): 689-693
Vittorio, F.; Santagati, N.A.; Lancetta, T.; Duro, F.; Arrigo Reina, R.; Cosentino, C. 1984: Alkyl and aryl derivatives of isoquinoline. II. Synthesis and pharmacologic activity of dialkylaminoalkyl esters of 1-chloro-3-carboxy-4-methylisoquinoline and the corresponding 4-phenyl derivative Il Farmaco; Edizione Scientifica 39(3): 217-228
Lagrota, M.H.; Ciribelli-Guimaräes, J.; Pereira, N.A.; Wigg, M.D.; Fonseca, M.E. 1982: Antiviral chemotherapy: in vitro activity of ribavirin on DNA and RNA viruses Revista Latinoamericana de Microbiologia 24(2): 121-124
Tornetta, B.; Guerrera, F.; Mazzarino, C. 1973: Relationship between the structure and antibacterial activity of aryl-thionamides. VI. Synthesis and in vitro tuberculostatic activity of 2-alkylthio-benzothiamides and 2-alkylthio-phenyl-vinylethionamides Bollettino Chimico Farmaceutico 112(12): 832-838
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Nishimura, T.; Toku, H.; Yamazaki, C.; Hasegawa, K.; Sakaguchi, H.; Nagaki, D. 1975: Antiviral compounds. IX. Synthesis and anti-influenza virus activity of bis-amidinohydrazones of glyoxal and methylglyoxal Kitasato Archives of Experimental Medicine 48(4): 171-181
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