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Substances with antiviral activity. XV. Preparation and antiherpes activity of alkyl- and acylamino-dihalogenated pyrimidines and pyridines

Giovanninetti, G.; Garuti, L.; Cavrini, V.; Roveri, P.; Mannini Palenzona, A.; Sinibaldi, P.; Fusco, P.A.

Il Farmaco; Edizione Scientifica 35(10): 879-886

1980

ISSN/ISBN: 0430-0920
PMID: 6256211
Document Number: 168381
Some dihalo-amino-pyrimidines and -pyridines were alkylated and acylated at the amino group. The resulting twenty-four compounds were then tested for their action on Herpes simplex virus infection in human HEp-2 cell cultures. Five compounds were active and 2-benzamido-3,5-dichloropyridine [(III B); Table I] showed the highest antiviral activity.

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