Synthesis and activity of pseudotripeptide inhibitors of HIV-1 protease containing D (-) -O- (benzyl) tartaric acid
Marastoni, M.; Fantin, G.; Bortolotti, F.; Tomatis, R.
Arzneimittel-Forschung 46(11): 1099-1101
1996
ISSN/ISBN: 0004-4172 PMID: 8955873 Document Number: 462666
Four HIV-1 protease inhibitors containing [(S,S)-O-(benzyl)tartaric acid]-Pro as a transition-state mimic were prepared and evaluated by a spectrophotometric assay. Two pseudotripeptide derivatives showed weak inhibitory activity similar to acetylpepstatin.
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