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Synthesis and activity of some new histone deacetylases inhibitors

Cheng, Y.-H.; Guo, Y.-S.; Han, H.-Z.; Wang, N.; Zhang, G.-H.; Guo, Z.-R.; Wu, S.

Yao Xue Xue Bao 45(6): 735-741

2010

ISSN/ISBN: 0513-4870
PMID: 20939182
Document Number: 647361
To explore novel histone deacetylase (HDAC) inhibitors with anti-tumor activity, twelve target compounds were synthesized, and their structures were confirmed by 1H NMR, MS and elemental analyses. Evaluation results in vitro showed that compound Ia exhibited potent inhibition against HDAC and is worth for further investigation. And compounds IIa, IIb, IIIa-IIIi possessed moderate HDAC inhibitory activity.

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