Antimetastatic activity of boro-amino acid analog protease inhibitors against B16BL6 melanoma in vivo
Kinder, D.H.; Elstad, C.A.; Meadows, G.G.; Ames, M.M.
Invasion and Metastasis 12(5-6): 309-319
1992
ISSN/ISBN: 0251-1789 PMID: 1298742 Document Number: 3795
Di- and tripeptide boro-amino acid analog protease inhibitors with specificity for chymotrypsin and elastase decrease the number of melanotic foci formed in the lungs of mice in the B16BL6 experimental metastatic tumor model. These effects were at significantly lower concentration than leupeptin or other natural chymotrypsin inhibitors previously reported. These results support the involvement of elastase and chymotrypsin in the metastatic process.
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