2-amino-3-phosphonopropionic acid (AP3) and its N-methyl analog improve learning and memory in rats
Winnicka, M.M.; Wiśniewski, K.; Kupczyk-Subotkowska, L.; Subotkowski, W.; Mastalerz, P.
Polish Journal of Pharmacology 47(1): 1-7
1995
ISSN/ISBN: 1230-6002 PMID: 7550543 Document Number: 441327
The influence of 2-amino-3-phosphonopropionic acid (AP3) an antagonist of metabotropic glutamate receptors and its N-methyl analog (N-methyl AP3) on acquisition, consolidation and recall of information in a passive avoidance situation was tested. Both compounds improved three examined parameters. The significant effect of AP3 appeared at the icv dose of 12.5 mu-g per rat when its influence on acquisition and consolidation was tested, and at the icv dose of 100 mu-g when its influence on retrieval process was evaluated. The significant improvement of acquisition of information was observed at the icv dose of 50 mu-g per rat of N-methyl AP3, but significant facilitation of consolidation and retrieval processes appeared at the higher dose of 100 mu-g per rat. Significant improvement of performance in a passive avoidance situation persisted in all experiments to the highest used dose of both compounds, 250 mu-g.