Psychotropic activity of N-methyl-2-amino-4-phosphonobutyric acid (N-methyl AP4)
Zalewska, A.; Winnicka, M.M.; Wiśniewski, K.
Polish Journal of Pharmacology 48(4): 415-423
1996
ISSN/ISBN: 1230-6002 PMID: 9112682 Document Number: 466985
We have previously reported that 2-amino-4-phosphonobutyric acid (AP4), an agonist of presynaptically located metabotropic glutamate receptors, administrated at a single intracerebroventricular (icv) injection facilitated learning and memory in a passive - and learning in an active avoidance situation, enhanced apomorphine stereotypy, and attenuated haloperidol catalepsy in rats. In the present study the effect of a single icv injection of N-methyl analogue of AP4 (N-methyl AP4), in the same behavioral tests was investigated in rats. The compound at the doses of 100 and 200 mu-g per rat significantly enhanced apomorphine stereotypy, at the dose of 75 mu-g per rat attenuated haloperidol-induced catalepsy, without having any influence on spontaneous locomotor activity estimated in the open field test. N-methyl AP4 at the doses of 75 and 100 mu-g per rat significantly facilitated acquisition of information, consolidation, and retrieval process in a passive avoidance situation. The compound significantly improved only acquisition of conditioned avoidance responses (CARs) at the doses of 50 and 75 mu-g per rat; the positive effect of N-methyl AP4 on consolidation and recall of CARs was insignificant. Methyl-substitution at N-position in AP4 did not change its effects in the performed behavioral tests.