An antimetastatic study of Arg-Asp (RD) on salivary adenoid cystic carcinoma in vivo
Li, F.; Yu, G.; Li, S.; Peng, S.; Fu, J.; Wu, D.
Zhonghua Kou Qiang Yi Xue Za Zhi 37(2): 87-89
2002
ISSN/ISBN: 1002-0098 PMID: 12475414 Document Number: 550996
To test the antimetastatic effects of Arg-Asp (RD) on salivary adenoid cystic carcinoma (SACC-LM) in vivo. RD was administered orally to experimental metastasized nude mice. The pulmonary metastatic foci number and survival were determined to assay the antimetastatic effects of RD. 30 mg/kg, 120 mg/kg of RD demonstrated an inhibitory effect on the pulmonary metastatic foci formation. All of the tested dosages (7.5 mg/kg, 30 mg/kg, 120 mg/kg) of RD prolonged the survival. Oral administration of RD has a antimetastatic effect on SACC-LM. RD is low toxicity.