Synthesis of new 6H-indolo[2,3-b] [1,8]naphthyridines and their specific inhibition of benzodiazepine receptor
Da Settimo, A.; Primofiore, G.; Ferrarini, P.L.; Mori, C.; Martini, C.; Pennacchi, E.; Lucacchini, A.
Il Farmaco; Edizione Scientifica 41(8): 577-585
1986
ISSN/ISBN: 0430-0920 PMID: 3017748 Document Number: 270415
Some 3-amino- and 3-hydroxy-8-halosubstituted 6H-indolo[2,3-b] [1,8]naphthyridines were synthesized and tested for their affinity for the benzodiazepine receptor in bovine cortical membranes. All prepared compounds were more active than the corresponding 8-unsubstituted derivatives. Moreover, among these compounds the 8-chloroindolonaphthyridines were clearly the most potent.
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