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Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. X--Synthesis and inhibition of benzodiazepine receptor binding of new 1,4-thiazine and 1,5-thiazepine polycondensed heterocycles with steroidal structure

Grandolini, G.; Ambrogi, V.; Perioli, L.; Giannaccini, G.; Lucacchini, A.; Martini, C.

Farmaco 51(3): 203-207

1996

ISSN/ISBN: 0014-827X
PMID: 8688143
Document Number: 455016
Some naphtho(1,2,-b)-s-triazolo(4,3-d)-1,4-thiazine and 1,5-thiazepine and s-triazolo(4',3'4,5)-1,4-thiazino(3,2-c)quinoline derivatives have been synthesized and tested for their ability to displace (3H)RO 15-1788 binding from bovine brain membranes. Several compounds showed moderate binding affinity for the benzodiazepine receptor.

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